![slapen](https://erasmusmc-amazingerasmusmc.s3.eu-central-1.amazonaws.com/wp-content/uploads/sites/2/2024/06/24131406/slapen-320x240.jpg)
Epidemiology
Fragmented sleep-wake rhythm precedes Alzheimer plaques in the brain
A fragmented sleep-wake rhythm, where people often transition from rest to active during the day and night, is already visible in the brain before the accumulation of the Alzheimer’s protein amyloid-beta. That has been shown by research from Erasmus MC involving over 300 residents of the Ommoord district in Rotterdam.